Ultrasound Mediated Smart Drug Delivery System

a Noninvasive approach for the delivery of Insulin from Nanofiber Film.

Abstract

Diabetes mellitus is a group of metabolic illness characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is related with long-term damage, dysfunction, and failure of various organs, in particular the eyes, kidneys, nerves, heart, and blood vessels. At an advanced level of diabetes mellitus, diabetic patients need to have insulin injections which is an invasive way and quite painful to administer drug. Researchers are aiming to improve the quality of life of a diabetic patient by bringing about a noninvasive administration of Insulin. The aspiration of this research is to develop a smart drug delivery system providing burst and sustained release of inulin. In this system biodegradable polymers ZEIN and PVA have been used to prepare drug loaded transdermal nanofiber film by electrospinning method and characterized by Fourier transform infrared (FTIR) and Scanning electron microscopy (SEM) and the release behavior of insulin from both PVA and ZEIN nanofiber films in vitro is performed by using UV VIS spectrophotometer. Further, efficacy of ultrasound has been tested in the delivery of insulin.